The NAESM African American MSM Leadership Conference on Health Disparities and Social Justice is our nation’s largest annual convening dedicated to exploring HIV prevention, care, treatment, policy, and research advances related to Black men who have sex with men. The conference provides an opportunity for Black MSM-serving organizations and individuals to share best practices and methodologies. It serves as a think tank and clearinghouse for Black MSM-related HIV research. It provides opportunities for showcasing effective grass roots initiatives and interventions. More recently, the conference has contextualized the Black MSM HIV epidemic within a broader health disparities, social justice, and human rights framework—a recognition that getting ahead of this disease requires addressing the social determinants and social context of health. The annual conference is central to NAESM’s organizational mission of providing national and local leadership to address the myriad health and wellness issues confronted by Black gay and bisexual men through advocacy, services, and education.